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The identity, nature, and relationships between the key players in a project, the who, is clearly a general project management issue. It is inseparable from the management of project uncertainty. It is the starting point in Figure 1.1, usefully revisited at this point. In any organizational setting, even small projects invariably involve two or more parties working together. Parties may be individuals, units of an organization, or organizations as a whole. The relationships between the various parties may be complex, often involving a hierarchy of contractual arrangements. Such relationships bring fundamental complications that have a profound in uence on project uncertainty and project risk. As indicated in Figure 1.1, later players and other interested parties may require attention as the project evolves. Indeed, project initiators may cease to dominate. The other interested parties in Figure 1.1 re ect the potentially important roles of regulators and others who are not direct players, but may require careful attention, because they are important sources of uncertainty. It is important to ensure a broad view of the who, to include all relevant interested parties, and a rich view, to distinguish individual players or groups within single organizations who may have signi cantly different agendas. For example, in marketing terms distinguishing between the purchaser and ultimate user of a product can be very important. A memorable illustration concerns the launch (some time ago) of a new carbon paper for copy typing that did not make black smudges on secretaries ngers and clothes. Initial marketing effort was targeted at corporate supply departments. It failed. A revised approach aimed at secretaries was an overwhelming success.

SCAMPI Standard CMMI Appraisal Method for Process Improvement scenario A description of a speci c interaction between a user and a system to accomplish some goal An instance of usage of the system A speci c path through a use case Often presented in the form of a story (IEEE Std 61012-1990)* script A sequence of computer commands written in batch language Section 508 An amendment to the Rehabilitation Act of 1973 that requires that any technology produced by or for federal agencies be accessible to people with disabilities It covers the full range of electronic and information technologies in the federal sector (Ch 1, [17]) security The establishment and application of safeguards to protect data, software, and computer hardware from accidental or malicious modi cation, destruction, or disclosure (Ch.

research were done, would pharmaceutical companies pour research funds into the search for a drug, or drugs, for the other 20% of the affected population or would they be content with 80% of the market, leaving the 20% as orphan genotypes If pharmacogenomic research were not used, would the pharmaceutical companies successfully develop a drug that would treat all 100% or would they abandon the whole market, including the 80% who could bene t from the existing drug How that question is answered may have major implications for whether the research has good or bad consequences, but, at this point, it is unanswerable It depends on too many unknown facts and may well vary from drug to drug, disease to disease Finally, whatever the general consequences of such a pharmacogenomic drug, its effects on minority groups are unknowable at this point.

It is tempting to think that members of American minority groups will be found disproportionately among those for whom developed drugs are either not safe or not effective, but this assumption may well be wrong It is based, at heart, on the myth that consistent genetic differences separate racial and ethnic groups We know they do not, in general but that does not mean that the frequency of some genetic variations of signi cance for pharmacogenomics may not vary by ethnicity So, what is to be done This dilemma argues strongly for incentives to encourage rms to nd drugs for orphan genotypes One route might be a revision of the Orphan Drug Act, which provides added market exclusivity to the makers of drugs with a small market, to cover drugs whose pharmacogenomic market is small.

Figure 11.5 suggests a probability of achieving the base plan completion date of about 0.15. This was an unsatisfactory outcome. Once it was con rmed that the picture portrayed by Figure 11.5 was valid, improving the prognosis was in order by changing the base plan or contingency plans with particular reference to key issues. In the process of industrial dispute data acquisition and analysis, the hypothesis that a carefully drafted contract with the yard would be an effective response was explored. Analysis suggested such contracts actually had little effect on these industrial disputes. Such industrial disputes mainly occurred during the last 10% of a contract if no more work was anticipated in that yard on completion. Recognition of this cause led to effective action: smoothing the ow of work to yards to the extent possible by all the oil companies involved. It was recognized that this resolved the particular problem diagnosed by Figure 11.5 and the more general industrial disputes problem. It was also recognized that this smoother work ow reduced jacket fabrication costs by avoiding bidding up the price when demand peaked. These changes contributed to improved risk ef ciency, both at the project level and the corporate level.

Direct grants, loans, and NIH funding could also encourage development of effective medications for as many people as possible This may have a disproportionately useful effect on minority groups, or it may not But, with pharmacogenomics, we all nd ourselves as potential carriers of such orphan genotypes Minority, plurality, or majority, we each live behind a Rawlsian veil of ignorance, not knowing whether this research will help us or hurt us (Rawls, 1971) As John Rawls argues, confronted by that uncertainty, we should hedge our bets and try to ensure that we will be well treated, no matter what our characteristics turn out to be Protection of those with orphan genotypes is an insurance policy for all of us that seems likely to be worth the price..